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Liver failure and death has been reported in cancer patients receiving concurrent medicationsincluding potentially hepatotoxic cytotoxic chemotherapy and antibioticsThe etiology of the liver failure is unclear.
A reduction in clearance and increase in elimination half-life are seen in patients older than 75 years compared to younger subjectssee Use In Specific Populations
No dosage adjustment is needed in patients with mild or moderate hepatic impairment.
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in a double-blind, us trial in 336 patients receiving a cyclophosphamide-based chemotherapy regimen containing either methotrexate or doxorubicin, zofran 8 mg administered twice a day, was as effective as zofran 8 mg administered 3 times a day in preventing nausea and vomiting.
