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Methotrexate – loop diuretics may increase blood levels of methotrexate and vice versa.

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Methotrexate can make you more likely to get infections or may worsen any current infectionsThereforewash your hands well to prevent the spread of infectionAvoid contact with people who have infections that may spread to otherssuch as chickenpoxmeaslesfluConsult your doctor if you have been exposed to an infection or for more details.

Examples of drugs that can cause interactions with methotrexate are listed below.

Measure liquid medicine carefullyUse the dosing syringe providedor use a medicine dose-measuring devicenot a kitchen spoon

Avoid exposure to sunlight or artificial UV rayssunlamps or tanning bedsespecially if you are being treated for psoriasisMethotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen.

Increased side effects from other drugsTaking methotrexate with certain medications raises your risk of side effects from those drugsExamples of these drugs include:

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in two of these cases, delayed methotrexate elimination was observed when high-dose methotrexate was coadministered with ppis, but was not observed when methotrexate was co-administered with ranitidine.

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