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Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in cardiovascular regulationFurthermore losartan does not inhibit ACEkininase IIthe enzyme that degrades bradykininConsequentlythere is no potentiation of undesirable bradykinin-mediated effects.
Measures are depending on the time of medicinal product intake and kind and severity of symptomsStabilisation of the cardiovascular system should be given priorityAfter oral intakethe administration of a sufficient dose of activated charcoal is indicatedAfterwardsclose monitoring of the vital parameters should be performedVital parameters should be corrected if necessary.
Control of high blood pressure should be part of comprehensive cardiovascular risk managementincludingas appropriatelipid controldiabetes managementantithrombotic therapysmoking cessationexerciseand limited sodium intakeMany patients will require more than 1 drug to achieve blood pressure goalsFor specific advice on goals and managementsee published guidelinessuch as those of the National High Blood Pressure Education Program’s Joint National Committee on PreventionDetectionEvaluationand Treatment of High Blood PressureJNC
Losartan is a synthetic oral angiotensin-II receptortype AT 1antagonistAngiotensin IIa potent vasoconstrictoris the primary active hormone of the renin/angiotensin system and an important determinant of the pathophysiology of hypertensionAngiotensin II binds to the AT 1 receptor found in many tissuese.gvascular smooth muscleadrenal glandkidneys and the heartand elicits several important biological actionsincluding vasoconstriction and the release of aldosteroneAngiotensin II also stimulates smooth muscle cell proliferation.
Some antihypertensive drugs have smaller blood pressure effectsas monotherapyin black patientsand many antihypertensive drugs have additional approved indications and effectse.gon anginaheart failureor diabetic kidney diseaseThese considerations may guide selection of therapy.
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according to the prescribing information for cozaar, the brand-name of losartan, increased urinary frequency is a possible side effect associated with this medication.
