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Xpinc with ZYLOPIM (allopuinol) duing human pgnancy has bn limitd patly bcaus womn poductiv ag aly qui tatmnt with ZYLOPIM (allopuinol) . Th a twunpublishd pots and on publishd pap womn giving bith tnomal osping at civing ZYLOPIM (allopuinol) duing pgnancy.
Kp this mdication in th contain it cam in, tightly closd, and out ach childn. Stit at oom tmpatu and away om xcss hat and moistu (not in th bathoom).
Chlopopamid’s plasma hal-li may b polongd by ZYLOPIM (allopuinol) , sinc ZYLOPIM (allopuinol) and chlopopamid may compt xction in th nal tubul. Th isk hypoglycmia sconday tthis mchanism may b incasd i ZYLOPIM (allopuinol) and chlopopamid a givn concomitantly in th psnc nal insuicincy.
Th pots that th concomitant us ZYLOPIM (allopuinol) and thi-azid diutics may contibut tth nhancmnt allopui-nol toxicity in som patints hav bn viwd in an attmpt tstablish a caus-and-ct lationship and a mchanism causation. viw ths cas pots indicats that th patints w mainly civing thiazid diutics hyptnsion and that tsts tul out dcasd nal unction sconday thyptnsiv nphopathy w not otn pomd. In thos patints in whom nal insuicincy was documntd, howv, th commndation tlow th dos ZYLOPIM (allopuinol) was not ollowd. Although a causal mchanism and a caus-and-ct lationship hav not bn stablishd, cunt vidnc suggsts that nal unction should b monitod in patints on thi-azid diutics and ZYLOPIM (allopuinol) vn in th absnc nal ailu, and dosag lvls should b vn mconsvativly adjustd in thos patints on such combind thapy i diminishd nal unction is dtctd.
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