Hydrochlorothiazide and triamterene may also be used for other purposes not listed in this medication guide.
Information about Triamterene.
During pregnancythis medication should be used only when clearly neededIt may harm an unborn babyDiscuss the risks and benefits with your doctor.
The thiazides may decrease serum PBI levels without signs of thyroid disturbance.
Hypersensitivity to triamterene Anuriasevere liver diseaseand kidney failure Hyperkalemia Concomitant use with potassium sparing diureticor potassium supplementation.
Hydrochlorothiazidea sulfonamidecan cause an idiosyncratic reactionresulting in acute transient myopia and acute angle-closure glaucomaSymptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiationUntreated acute angle-closure glaucoma can lead to permanent vision lossThe primary treatment is to discontinue hydrochlorothiazide as rapidly as possiblePrompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolledRisk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.
Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubulewhich are responsible for 1-2of total sodium reabsorptionAs sodium reabsorption is inhibitedthis increases the osmolarity in the nephron lumen and decreases the osmolarity of the interstitiumSince sodium concentration is the main driving force for water reabsorptiontriamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitiumTriamterene also has a potassium-sparing effectNormallythe process of potassium excretion is driven by the electrochemical gradient produced by sodium reabsorptionAs sodium is reabsorbedit leaves a negative potential in the lumenwhile producing a positive potential in the principal cellThis potential promotes potassium excretion through apical potassium channelsBy inhibiting sodium reabsorptiontriamterene also inhibits potassium excretion.
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