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A mutation in the MDR1multidrug resistantgeneresponsible for encoding an important blood-brain barrier proteinresults in hypersensitivitydilation of the pupilssalivationsomnolence/sleepinessdepressiondisorientationloss of muscle coordinationtremorscoma and possible deathto ivermectin in some dog breedsspecificallyR
The MDR1 gene produces the P-glycoproteina membrane transport protein active in the liver and blood-brain barrier.
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stromectol is available in 3-mg tablets containing the following inactive ingredients microcrystalline cellulose, pregelatinized starch, magnesium stearate, butylated hydroxyanisole, and citric acid powder anhydrous .