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Celebrexcelecoxibis a nonsteroidal anti-inflammatory drugNSAIDCelecoxib works by reducing hormones that cause inflammation and pain in the body.
In adult patients who are known or suspected to be poor CYP2C9 metabolizers based on genotype or previous history/experience with other CYP2C9 substratessuch as warfarinphenytoininitiate treatment with half of the lowest recommended dose.
NSAIDs cause an increased risk of serious gastrointestinalGIadverse events including bleedingulcerationandperforation of the stomach or intestineswhich can be fatalThese events can occur at any time during use and without warning symptomsElderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for seriousGIeventssee WARNINGS AND PRECAUTIONS]
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