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Gastroesophageal Reflux Disease Associated with a History of Erosive Esophagitis.
In neonatal/juvenile animalsrats and dogstoxicities were similar to those observed in adult animalsincluding gastric alterationsdecreases in red cell massincreases in lipidsenzyme induction and hepatocellular hypertrophyAn increased incidence of eosinophilic chief cells in adult and neonatal/juvenile ratsand atrophy of chief cells in adult rats and in neonatal/juvenile dogswas observed in the fundic mucosa of stomachs in repeated-dose studiesFull to partial recovery of these effects were noted in animals of both age groups following a recovery period.
Systemic lupus erythematosusSLEis less commonly reported than CLE in patients receiving PPIsPPI associated SLE is usually milder than non-drug induced SLEOnset of SLE typically occurred within days to years after initiating treatment primarily in patients ranging from young adults to the elderlyThe majority of patients presented with rashhoweverarthralgia and cytopenia were also reported.
Confusiondepressionhallucinationsand disorientationespecially in predisposed patientshas occurred with useand was aggravated in patients with preexisting conditionsRef]
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it is part of a larger class of medications known as proton pump inhibitors ppi , which also include prilosec, prevacid, protonix and others.
