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Information about Premarin.
An increased risk of stroke and DVT has been reported with estrogen-alone therapyAn increased risk of PEDVTstroke and MI has been reported with estrogen plus progestin therapyShould any of these occur or be suspectedestrogen with or without progestin therapy should be discontinued immediatelyRisk factors for arterial vascular diseasefor examplehypertensiondiabetes mellitustobacco usehypercholesterolemiaand obesityand/or venous thromboembolismVTEfor examplepersonal history or family history of VTEobesityand systemic lupus erythematosusshould be managed appropriately.
Certain estrogen products may also be used by women after menopause to prevent bone lossosteoporosisHoweverthere are other medicationssuch as raloxifenebisphosphonates including alendronatethat are also effective in preventing bone loss and may be saferThese medications should be considered for use before estrogen treatment.
Premarin is also used as part of breast cancer treatment in both women and men.
Additional postmarketing adverse reactions have been reported in patients receiving other forms of hormone therapy.
There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogensAdding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasiawhich may be a precurs or to endometrial cancerAdequate diagnostic measuresincluding directed or random endometrial sampling when indicatedshould be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleedingsee WARNINGS AND PRECAUTIONS
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